Abstract | Adaptive Possibilities of The Cardiovascular System in Adolescents with Myocardial Pathology

Authors: Henry Boateng, Tatyana  Holovko Scientific advisor: Tatyana  Holovko Ph.D. Department of Pediatrics

Kharkiv National University V.N.Karazin

The aim of our study was to study the functional changes in the cardiovascular system (CVS) and its adaptive capacities in children with non-inflammatory heart diseases. 62 patients with non- inflammatory myocardial diseases were  examined, 39  of them  were  boys and 23  girls, whose average age was 14.56 ± 0.24 years. The control group consisted of 41 practically healthy peers, including 14 girls and 27 boys. The average age is 14.68 ± 0.36 years.

Research methods: six-minute walk test (6MWT), the calculation of the endurance coefficient (EC) and the Robinson index (IR) both before and after the physical activity. At rest, the adaptation potential was also calculated.

The  main  group   was  divided   into  two  subgroups  depending  on  the   pathology  of  the myocardium. The first subgroup consisted of 30 patients with undifferentiated systemic connective tissue dysplasia (USCTD) with the  presence of mitral valve prolapse of varying severity, mostly  I degree without  regurgitation. The second subgroup includes 32  patients with various rhythm  and conduction disturbances (RCD). Adaptation potential in children from the control  group  was within the normal range and amounted to 1.81 ± 0.05. In children with myocardial pathology, this indicator was significantly higher (2.56 ± 0.09, p < 0.001 in adolescents with USCTD; 2.18 ± 0.06 p < 0.001 in adolescents with RCD) than  in the control group, but was within the satisfactory adaptation of the CVS.

The endurance coefficient before 6MWT was significantly higher in patients with RCD (2.05 ± 0.08, p < 0.05 in adolescents with RCD; 1.97 ± 0.15 in children with USCTD versus 1.69 ± 0.09 in adolescents of the  control  group).  After 6MWT, EC increased in all studied adolescents, which indicates an increase in the functional capabilities of the cardiovascular system in response to the physical activity, but a significant increase was observed in patients with USCTD (2.27 ± 0.12 in adolescents with RCD; 2.36 ± 0.09 , p < 0.05 in adolescents with USCTD versus 2.06 ± 0.15 in adolescents of the control group). After 6MTH, IR (Robinson Index) increased in all the studied adolescents, which indicates an increase in the work done by the heart, but no significant difference was found. Thus, in adolescents with non-inflammatory heart diseases, the  functional state of the  cardiovascular system is within the limits of satisfactory adaptation. In response to the minimum  physical activity, the functionality of this system is increased.

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